正念减压对肿瘤病人癌因性疲乏及生存质量干预效果的Meta分析

Effect of mindfulness-based stress reduction on cancer-related fatigue and quality of life in cancer patients:a Meta-analysis

[目的]系统评价正念减压对肿瘤病人癌因性疲乏及生存质量的干预效果。[方法]计算机检索国内外有关正念减压疗法对癌因性疲乏干预效果的随机对照试验研究,由2位研究者根据纳入和排除标准筛选文献,并进行资料提取和质量评价,采用Revman 5.3软件进行分析。[结果]最终纳入17项研究。Meta分析结果显示:正念减压能改善肺癌及乳腺癌病人癌因性疲乏[肺癌:SMD=-1.17,95%CI(-1.98,-0.37),P=0.004;乳腺癌:SMD=-0.83,95%CI(-1.30,-0.36),P=0.000 6]、缓解焦虑[SMD=-0.17,95%CI(-0.31,-0.03),P=0.01]、抑郁[SMD=-1.12,95%CI(-1.93,-0.32),P=0.006]并能提高睡眠质量[SMD=-1.24,95%CI(-2.22,-0.26),P=0.01]。[结论]现有证据表明,正念减压能有效缓解肿瘤病人癌因性疲乏,在一定程度可以缓解病人负性情绪,提高睡眠质量。

Objective:To evaluate the effect of mindfulness-based stress reduction on cancer-related fatigue and quality of life in cancer patients.Methods:Randomized controlled trials on the effects of mindfulness-based stress reduction on cancer-related fatigue were retrieved by computer in China and abroad.The literatures were screened by two researchers independently based on inclusion and exclusion criteria.Then data extraction and quality evaluation were performed.RevMan 5.3 software was used for meta-analysis.Results:Seventeen studies were included.meta-analysis showed that mindfulness-based stress reduction could relieve cancer-related fatigue in patients with lung cancer and breast cancer[lung caner:SMD=-1.17,95%CI(-1.98,-0.37),P=0.004;breast cancer:SMD=-0.83,95%CI(-1.30,-0.36),P=0.000 6],reduce anxity[SMD=-0.17,95%CI(-0.31,-0.03),P=0.01]and alleviate depression[SMD=-1.12,95%CI(-1.93,-0.32),P=0.006],improve sleep quality[SMD=-1.24,95%CI(-2.22,-0.26),P=0.01].Conclusion:Current evidences show that mindfulness-based stress reduction can effectively alleviate cancer-related fatigue in cancer patients,reduce negative emotions to some extent and improve the quality of sleep.