期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肠上皮细胞中内质网应激与动物肠道炎症机制的研究进展 被引量：4

Research Progress of Endoplasmic Reticulum Stress and Intestinal Inflammation Mechanism in Intestinal Epithelial Cells
下载PDF
导出
摘要 近年来,内质网应激参与动物炎症性肠病发病机制的研究引起了广泛关注,未折叠或错误折叠的蛋白质在内质网腔中过量积累而引发内质网应激,持续的内质网应激则会导致动物肠黏膜屏障损伤并诱发肠道炎症。本文就内质网应激发生机制、未折叠蛋白质反应及内质网应激与肠道炎症互作机制进行了综述,旨在为防治动物肠道炎症提出新的治疗策略。 In recent years,the study of endoplasmic reticulum stress involved in the pathogenesis of inflamma⁃tory bowel disease in animals has caused wide attention,unfolded or misfolded proteins accumulate in the lu⁃men of the endoplasmic reticulum and cause endoplasmic reticulum stress,persistent endoplasmic reticulum stress can lead to intestinal mucosal barrier damage and induce intestinal inflammation.This paper reviewed the endoplasmic reticulum stress relieving mechanism,unfolded protein response and interaction mechanism of en⁃doplasmic reticulum stress with intestinal inflammation,aimd to propose a new therapeutic strategy for preven⁃ting and curing intestinal inflammation in animals.
作者 文伟 陈凤鸣 黄兴国 李颖慧 WEN Wei;CHEN Fengming;HUANG Xingguo;LI Yinghui(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Co⁃Innovation Center of Animal Production Safety,Changsha 410128,China)
机构地区 湖南农业大学动物科学技术学院 湖南省畜禽安全生产协同创新中心
出处 《动物营养学报》 CAS CSCD 北大核心 2020年第2期530-539,共10页 CHINESE JOURNAL OF ANIMAL NUTRITION
基金 国家自然科学基金青年科学基金项目（31802074） 湖南省自然科学基金青年基金项目（2019JJ50264） 农业领域重点研发项目（2017NK2310)
关键词 内质网应激 肠道炎症 未折叠蛋白质 肠上皮细胞 endoplasmic reticulum stress intestinal inflammation unfolded protein intestinal epithelial cells
分类号 S811.2 [农业科学—畜牧学]
  • 相关文献

参考文献5

二级参考文献44

  • 1Ian G. CHARLES,Salvador MONCADA.Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response[J].Cell Research,2005,15(1):63-65. 被引量：7
  • 2Adolph, T.E., Tomczak, M.F., Niederreiter, L., Ko, H.J., Bock, J., Martinez-Naves, E., Glickman, J.N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., Flak, M.B., Cusick, J.L., Kohno, K., lwawaki, T., Billmann-Born, S., Raine, T., Bharti, R., Lucius, R., Kweon, M.N., Marciniak, S.J., Choi, A., Hagen, S.J., Schreiber, S., Rosenstiel, P., Kaser, A., and Blumberg, R.S. (2013). Paneth cells as a site of origin for intestinal inflammation. Nature 503,272 276.
  • 3Anderson, C.A., Boucher, G., Lees, C.W., Franke, A., D'Amato, M., Taylor, K.D., Lee, J.C., Goyette, P., Imielinski, M., Latiano, A., Lagace, C., Scott, R., Amininejad, L., Bumpstead, S., Baidoo, L., Baldassano, R.N., Barclay, M., Bayless, T.M., Brand, S., Buning, C., Colombel, J.F., Denson, L.A., De Vos, M,, Dubinsky, M., Edwards, C., Ellinghaus, D., Fehrmann, R.S, Floyd, J.A., Florin, T., Franchimont, D., Franke, L., Georges, M., Glas, J., Glazer, N.L., Guthery, S.L., Haritunians, T., Hayward, N.K., Hugot, J.P., Jobin, G., Laukens, D., Lawrance, I., Lemann, M., Levine, A., Libioulle, C., Louis, E., McGovern, D.P., Milla, M., Montgomery, G.W., Morley, K.L, Mowat, C., Ng, A., Newman, W., Ophoft; R.A., Papi, L., Pahnieri, O., Peyrin-Biroulet, L., Panes, J., Phillips, A., Prescott, N.J., Proctor, D.D., Roberts, R., Russell, R., Rutgeerts, P., Sanderson, J., Sans, M., Schumm, P., Seibold, F., Sharma, Y., Simms, L.A., Seielstad, M., Steinhart, A.H., Targan, S.R., van den Berg, L.H., Vatn, M., Verspaget, H., Waiters, T., Wijmenga, C., Wilson, D.C., Westra, H.J., Xavier, R.J., Zhao, Z.Z., Ponsioen, C.Y., Andersen, V., Torkvist, L., Gazouli, M., Anagnou, N.P., Karlsen, T.H., Kupcinskas, L., Sventoraityte, J., Mansfield, J.C., Kugathasan, S., Silverberg, M.S., Halfvarson, J., Rotter, J.l., Mathew, C.G., Griffiths, A.M., Gearry, R., Ahmad, T., Brant, S.R., Chamaillard, M., Satsangi, J., Cho, J.H., Schreiber, S., Daly, M.J., Barrett, J.C., Parkes, M., Annese, V., Hakonarson, H., Radford-Smith, G., Duerr, R.H., Vermeire, S., Weersma, R.K., and Rioux, J.D. (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43. 246-252.
  • 4Atarashi, K., Tanoue, T., Shima, T., lmaoka, A., Kuwahara, T., Momose,Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, II, Umesaki, Y., Itoh, K., and Honda, K. (2011). Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331,337-341.
  • 5Ayabe, T., Satchell, D.P., Wilson, C.L., Parks, W.C., Selsted, M.E., and Ouellette, A.J. (2000). Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1, 113-118.
  • 6Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., Brant, S.R., Silverberg, M.S., Taylor, K.D., Barmada, M.M., Bitton, A., Dassopoulos, T., Datta, L.W., Green, T., Griffiths, A.M., Kistner, E.O., Murtha, M.T., Regueiro, M.D., Rotter, J.1., Schumm, L.P., Steinhart, A.H., Targan, S.R., Xavier, R.J., Libioulle, C., Sandor, C., Lathrop, M., Belaiche, J., Dewit, O., Gut, I., Heath, S., Laukens, D., Mni, M., Rutgeerts, P., Van Gossum, A., Zelenika, D., Franchimont, D., Hugot, J.P., de Vos, M., Vermeire, S., Louis, E., Cardon, L.R., Anderson, C.A., Drummond, H., Nimmo, E., Ahmad, T., Prescott, N.J., Onnie, C.M., Fisher, S.A., Marchini, l., Ghori, J., Bumpstead, S., Gwilliam, R., Tremelling, M., Deloukas, P., Mansfield, J., Jewell, D., Satsangi, J., Mathew, C.G., Parkes, M., Georges, M., and Daly, M.J. (2008). Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40, 955-962.
  • 7Bevins, C.L., and Salzman, N.H. (2011). Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9, 356-368.
  • 8Billmann-Born, S., Till, A., Arlt, A., Lipinski, S., Sina, C., Latiano, A., Annese, V., Hasler, R., Kerick, M., Manke, T., Seegert, D., Hanidu, A., Schafer, H., van Heel, D., Li, J., Schreiber, S., and Rosenstiel, P. (2011). Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. J Immunol 186, 40274038.
  • 9Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Lob, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., Stone, C.D., Brunt, E.M., Xavier, R.J., Sleckman, B.P., Li, E., Mizushima, N., Stappenbeck, T.S., and Virgin, H.W.4th. (2008). A key role for autophagy and the autophagy gene Atgl611 in mouse and human intestinal Paneth cells. Nature 456, 259-263.
  • 10Cadwell, K., Patel, K.K., Maloney, N.S., Liu, T.C., Ng, A.C., Storer, C.E., Head, R.D., Xavier, R., Stappenbeck, T.S., and Virgin, H.W. (2(110). Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atgl6L1 phenotypes in intestine. Cell 141, 1135-1145.

共引文献21

同被引文献27

引证文献4

二级引证文献2

动物营养学报
2020年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部