MAPK信号通路介导的自噬调控破骨细胞分化的研究进展

Progress on Autophagy in Regulation of Osteoclast Differentiation via MAPK Signaling Pathway

破骨细胞具有骨吸收活性,与骨组织稳态密切相关。丝裂原活化蛋白激酶(MAPK)通路是细胞介导胞内外刺激传导的信号通路,参与细胞的增殖、分化、自噬等多种生理过程。MAPK介导的自噬在调控破骨细胞分化中具有重要作用。探究MAPK的三条经典通路(ERK1/2、JNK及p38 MAPK信号通路)介导的自噬与破骨细胞分化之间的关系,对于寻找与破骨细胞相关的骨代谢疾病的新疗法具有重要意义。

Mature osteoclasts have bone resorption activity,which is closely related to the homeostasis of bone tissue.Mitogen-activated protein kinase(MAPK)pathway is a signal pathway that mediates intracellular and extracellular stimulus transduction,and is involved in cell proliferation,differentiation,autophagy and other physiological processes.Autophagy mediated by MAPK pathways plays an important role in regulation of osteoclast differentiation.Exploring the relationship between autophagy mediated by three classic MAPK pathways(ERK1/2,JNK and p38 MAPK signaling pathways)and osteoclast differentiation is of great significance for finding new therapies for osteoclast related bone metabolic diseases.