医疗气体在器官移植领域中的应用研究进展

Progress in the application of medical gases in organ transplantation

器官移植是目前治疗终末期器官衰竭的最有效方案。供器官来源短缺以及移植相关损伤是器官移植领域的主要问题,需完善现有的技术手段或开发新的治疗方法,以提高供器官质量及减轻移植相关损伤。医疗气体是为医疗需求提供解决方案的药物气体分子,包括氢气、硫化氢、一氧化氮、一氧化碳、二氧化碳和氙气等。这些气体在高浓度时可能具有毒性或一定危险性,但在低浓度时可通过抗炎、抗氧化和抗凋亡等作用减轻供器官损伤,发挥一定的治疗作用。本文就近年来医疗气体在器官移植领域的应用研究进展进行综述。

Organ transplantation is the ultimate treatment of end-stage diseases of various organs.Organs shortage and transplantation-induced injury are the main problems in organ transplantation.Existing or new methods need to be developed to improve the quality of donor organs and reduce post-transplantation injury.Medical gases are pharmaceutical gaseous molecules which offer solutions for medical needs,including hydrogen,hydrogen sulfide,nitric oxide,carbon monoxide,carbon dioxide,Xenon and so on.These gases may be harmful or toxic gases at high concentrations,but can be used at low concentrations to reduce organ injury through anti-inflammatory,antioxidant,anti-apoptosis and so on.In this paper,the research progress of these medical gases on organ transplantation will be reviewed.