抗病毒药物滴眼对巨细胞病毒阳性青光眼睫状体炎综合征患者炎症反应及眼压的影响

Influence of antiviral eye drops on inflammatory response and intraocular pressure of cytomegalovirus-positive patients with Possner-Schlossman syndrome

目的探讨抗病毒药物滴眼对巨细胞病毒(cytomegalovirus,CMV)阳性青光眼睫状体炎综合征患者炎症反应水平及眼压的影响。方法选取我院2015年4月至2018年10月收治的CMV阳性青光眼睫状体炎综合征患者共73例73眼,均给予20 g·L^-1更昔洛韦滴眼液治疗,比较患者治疗前后角膜后沉着物(keratic precipitates,KP)分布情况、房水闪辉分布情况、激素使用率、激素用量、眼压、降眼压药物使用率及降眼压药物使用种类。结果患者治疗后羊脂状KP、钱币状KP及房水闪辉比例分别为52.05%、2.74%、0.00%,均显著低于治疗前的87.67%、26.03%、12.33%(均为P<0.05)。患者治疗后激素使用率和激素用量分别为47.95%,每天0(0~3)次,均显著低于治疗前的90.41%,每天3(0~4)次(均为P<0.05)。患者治疗后眼压、降眼压药物使用率及使用种类分别为(15.97±4.23)mmHg(1 kPa=7.5 mmHg)、41.10%、每天0(0~3)种,均显著低于治疗前的(26.34±5.10)mmHg、72.60%、每天2(0~3)种(均为P<0.05)。结论抗病毒药物滴眼用于CMV阳性青光眼睫状体炎综合征患者可显著提高炎症反应控制效果,降低眼压,减少激素和降眼压药物使用,具有良好的临床应用价值。

Objective To investigate the influence of antiviral eye drops on inflammatory response and intraocular pressure of cytomegalovirus(CMV)-positive patients with Possner-Schlossman syndrome(PSS).Methods Totally 73 eyes in 73 CMV-positive patients with PSS were selected in our hospital from April 2015 to October 2018,and treated with 20 g·L^-1 Ganciclovir Eye Drops.Keratic precipitates(KP)distribution,aqueous flare distribution,hormone used rate,hormone dosage,intraocular pressure levels,used rate and types of ocular hypotensive agents were compared before and after treatment.Results The ratios of mutton-fat KP,nummular KP and aqueous flare were 52.05%,2.74%and 0.00%after treatment,all of which were respectively lower than 87.67%,26.03%and 12.33%before treatment,and statistical differences were observed(all P<0.05).The hormone used rate and hormone dosage were 47.95%and 0(0-3)times/day after treatment,and both of which were significantly lower than 90.41%and 3(0-4)times/day before treatment,and there were statistical differences(all P<0.05).The intraocular pressure level,used rate and types of ocular hypotensive agents were(15.97±4.23)mmHg,41.10%and 0(0-3)after treatment,all of which respectively lower than(26.34±5.10)mmHg,72.60%and 2(0-3)before treatment,and statistical differences were found(all P<0.05).Conclusion Antiviral eye drops can efficiently improve the control effects of inflammatory reaction,reduce intraocular pressure levels and decrease the use of hormones and antihypertensive drugs in the treatment of CMV-positive patients with PSS that has a good clinical value.