纳米纤维素在控释长效抗菌复合材料中的应用

Application of Nanofibrillated Cellulose in Controlled Release and Long-term Antibacterial Composites

纳米纤维纤维素由于其良好的生物相容性、稳定性和可改性等优点,在抗菌材料中得到了广泛的应用,并可以作为制备纳米银的模板材料。为了研究银纳米粒子的沉积过程和抗菌性能,采用纳米纤维氧化法制备了双醛纳米纤维素,并用于引发银镜反应。成功制备了粒径约为31.07 nm的银纳米粒子,并将其均匀地固定在DATNFC上。该复合材料对金黄色葡萄球菌和大肠杆菌均具有良好的抗菌活性。双醛纳米纤维素诱导银离子缓慢释放,银离子的释放可控,释放周期超长。本研究为基于双醛纳米纤维纤维素/银纳米粒子复合材料制备绿色、超长期抗菌材料提供了一条新颖、简单、环保的途径,为银纳米粒子的快速高效还原开辟了新的窗口。合成的DATNFC@Ag复合材料可进一步应用于功能性生物医学材料领域。

Nanofibrillated cellulose is becoming popular in antibacterial material due to its favorable biocompatibility,stability and modifiable properties,which give it a great potential as a template for the deposition of silver nanoparticles.To investigate the deposition procedure and antibacterial ability of Ag NPs,dialdehyde nanofobril-lated cellulose prepared by oxidation of nanofibers was used to initiate the silver mirror reaction.Silver nanopar-ticles(~31.07 nm)were successfully fabricated and uniformly anchored onto DATNFC.The composites exhibited efficient antibacterial activity against both Staphylococcus aureus and Escherichia coli.Dialdehyde nanofobrillat-ed cellulose induced silver ions release in a slow way,which displayed a controllable release of silver ions and an ultra-long Ag+release period.This study offers a novel,simple and eco-friendly route for the fabrication of green and super long-term antibacterial materials based on dialdehyde nanofibrillated cellulose/silver-nanoparticle com-posites,and opens a new window for the rapid and efficient reduction of silver nanoparticles.The synthetized DATNFC@Ag hybrids could be further applied in the field of functional biomedical materials.