胰岛素抵抗在非酒精性脂肪性肝病发病中的作用及荷丹片在非酒精性脂肪性肝病中的治疗效果

The role of insulin resistance in the pathogenesis of nonalcoholic fatty liver disease and the effect of Hedan tablets in the treatment of nonalcoholic fatty liver disease

目的分析评价胰岛素抵抗在非酒精性脂肪性肝病发病中的作用及荷丹片在非酒精性脂肪性肝病中的治疗效果。方法将2016年1月至2019年1月于潍坊市寒亭区人民医院接受非酒精性脂肪性肝病治疗的60例患者作为研究对象,60例患者接受为期8周的治疗,进而比较60例研究对象治疗前后的血脂、血糖(空腹及餐后2h)、胰岛素(空腹及餐后2h)以及肝功能(ALT、AST)。结果治疗前后60例患者的TG(甘油三酯)和TC(总胆固醇)水平、LDL(低密度脂蛋白)比较,差异均有统计学意义(P<0.05),治疗前后患者的血糖(空腹及餐后2h)、胰岛素(空腹及餐后2h)差异均有统计学意义(P<0.05),治疗前后患者的肝功能(ALT、AST)差异均有统计学意义(P<0.05)。结论对非酒精性脂肪性肝病发病患者施以荷丹片,可以有效的改善患者的血脂异常和胰岛素抵抗,值得在临床治疗中广泛应用。

Objective To analyze and evaluate the role of insulin resistance in the pathogenesis of non-alcoholic fatty liver disease and the therapeutic effect of Hedan tablets in non-alcoholic fatty liver disease.Methods Between January 2016 and January 2019 in our hospital nonalcoholic fatty liver disease treatment of 60 patients as the research object,60 patients were treated for 8 weeks,and then compare the 60 cases of study object before and after treatment of blood lipids,blood glucose,fasting and postprandial 2 hours,insulin(fasting and postprandial 2 hour)and liver function(ALT,AST).Results 60 patients before and after the treatment of TG(triglyceride)and TC(Total cholesterol)levels,LDL(low-density lipoprotein)comparison,the difference had statistical significance(P<0.05),before and after treatment in patientswith blood glucose,fasting and postprandial 2 hours,insulin(fasting and postprandial 2 hour)difference had statistical significance(P<0.05),patients before and after the treatment of liver function(ALT,AST)difference had statistical significance(P<0.05).Conclusion applying Hedan tablets to the patients with non-alcoholic fatty liver disease can effectively improve the patients'dyslipidemia and insulin resistance,which is worthy of extensive application and promotion in clinical treatment.