益气活血温阳颗粒对慢性心力衰竭患者左室功能的临床研究

Effect of Yiqi Huoxue Wenyan Particle on Left Ventricular Functionin Patients with Chronic Heart Failure

目的:研究益气活血温阳颗粒对慢性心力衰竭患者左室功能的影响。方法:选取我院心内科病房收治的慢性心力衰竭患者60例,将其随机分为对照组30例和观察组30例。对照组根据心衰指南要求予以药物治疗,观察组在对照组治疗基础上加服益气活血温阳颗粒,疗程均为4周。在治疗前后分别送检两组患者的血浆BNP水平,超声心动图检查左室舒张末期内径(LVEDd)、左心室射血分数(LVEF)、舒张早期流速峰值(EPFV)/舒张晚期流速峰值(APFV)(E/A),并完善六分钟步行试验、填写明尼苏达心力衰竭生活质量问卷(MLHFQ),并比较结果。结果:观察组患者总有效率为86.7%,明显高于对照组(70%,P<0.05)。两组的血浆BNP水平、LVEDd在治疗后显著下降,LVEF、E/A在治疗后显著升高(P<0.05),且观察组效果优于对照组(P<0.05);两组的MLHFQ评分在治疗后显著下降,六分钟步行距离在治疗后显著升高(P<0.05),且观察组效果优于对照组(P<0.05);结论:益气活血温阳颗粒治疗慢性心力衰竭疗效显著,能改善左室功能,提高患者的生活质量和活动能力,安全有效,值得推广。

Objective: To investigate the effect of Yiqi HuoxueWenyang Particle on left ventricular function in patients with chronic heart failure. Methods: A total of 60 hospitalized patients with chronic heart failure were selected, and were randomly divided into treatment group and control group, with 30 cases in each group. Patients in control group were treated with medicine under guidelines. On this basis, the patients in treatment group were treated with Yiqi HuoxueWenyang Particle. The course of treatment was 4 weeks. Then BNP was measured, LVEDd, LVEF and E/A were detected, the Minnesota heart failure quality of life questionnaire(MLHFQ)was investigated. These results of treatment group and control group were observed and evaluated. Results: There were statistical differences on the total effective rate between the treatment group(86.7%)and control group(70%,P<0.05).After treatment, the levels of BNP 、LVEDd in the two groups were significantly decreased, LVEF and E/A were significantly increased compared with those before treatment(P<0.05). And the levels of BNP、LVEDd in the treatment group were lower than those in the control group(P<0.05), LVEF and E/A in the treatment group were higher than those in the control group(P<0.05). After treatment,the MLHFQ scores in the two groups were significantly decreased(P<0.05), 6 min walk distance were significantly increased(P<0.05). And the MLHFQ scores in treatment group were lower than those in the control group(P<0.05), 6 min walk distance in treatment group were higher than those in the control group(P<0.05). Conclusion: Yiqi HuoxueWenyang Particle can improve the left ventricular function, improve the quality of life in patients with chronic heart failure. It is worthy of clinical further promotion and discussion.