HIF-1在非小细胞肺癌中的研究进展

Research Progress of HIF-1 in Non-small Cell Lung Cancer

肺癌是目前全球范围内发病率和死亡率最高的恶性肿瘤,缺氧诱导因子(Hypoxia-Inducible Factors-1,HIF-1)在乏氧环境下广泛存在于人体中,调节机体对缺氧的反应,调控细胞氧平衡和诱导缺氧基因的表达,参与非小细胞肺癌细胞增殖凋亡、侵袭转移和肿瘤组织新生血管形成,并影响非小细胞肺癌的治疗和预后。本文就HIF-1与非小细胞肺癌的相关研究进展进行综述。

Lung cancer is the most common cancer with the highest morbidity and mortality in the world,HIF-1 exist widely in human body in hypoxic environment.It is involved in regulating the body's response to hypoxia,regulating the cell oxygen balance and inducing the expression of hypoxia genes,participating in the proliferation and apoptosis of non-small cell lung cancer cells,invasion and metastasis,and the formation of tumor tissue neovascularization,and affecting the treatment and prognosis of non-small cell lung cancer.This article reviews the recent advances in HIF-1 and NSCLC.