慢阻肺炎性标志物及其与肺功能相关性研究

Inflammatory markers of chronic obstructive pulmonary disease and their relationship with lung function

慢性阻塞性肺疾病(COPD)是一种慢性的可引起持续呼吸症状和气流受限的具有高住院率和死亡率的肺部疾病。在急性发作期间发生氧化应激时可引起急性时相蛋白和炎症细胞数量增加,促使巨噬细胞和中性粒细胞浸润,从而促进肺内炎症,这些促炎蛋白和细胞因子会从肺部"溢出"到全身循环中,导致全身低度炎症和血液中炎症生物标志物的增加,从而影响肺功能下降。多种炎症生物标志物已经被证实与肺功能相关,准确识别和验证与肺功能受损相关的血液炎症生物标志物具有重要意义。本文主要讲述慢性阻塞性肺疾病急性加重期炎症指标及肺功能的相关性研究进展。

Chronic obstructive pulmonary disease(COPD)is a chronic pulmonary disease with high hospitalization rate and mortality,which can cause persistent respiratory symptoms and airflow restriction.In the event of oxidative stress during an acute attack,it may cause an increase in the number of acute phase proteins and inflammatory cells,leading to the infiltration of macrophages and neutrophils,thereby promoting intrapulmonary inflammation,These pro-inflammatory proteins and cytokines"overflow"from the lungs to the systemic circulation,resulting in low systemic inflammation and the increase of inflammatory biomarkers in the blood,thus affecting the decline of lung function.A variety of inflammatory biomarkers have been shown to be associated with lung function It is of interest to identify and validate blood inflammation biomarkers that are associated with impaired lung function,as these might signal inflammatory mechanisms that can be targeted in order to prevent lung function decline.