生血宁片和琥珀酸亚铁片治疗妊娠合并贫血患者的临床效果评估

Clinical Evaluation of Shengxuening Tablets and Ferrous Succinate Tablets in the Treatment of Patients with Pregnancy Complicated with Anemia

目的研究生血宁片和琥珀酸亚铁片在临床上治疗妊娠合并贫血患者的效果。方法选取在该院接治的早期妊娠合并贫血患者,选取时间为2017年1月-2018年1月,选择例数是200例,选取对象按照数字随机分配法将对象分为两组对照组与观察组,对照组患者使用生血宁片进行治疗,观察组使用琥珀酸亚铁片进行治疗,观察这两组患者在治疗结束后的血红蛋白、血清铁蛋白、红细胞计数、总铁结合率的改善情况与不良反应及妊娠结局。结果观察组的血红蛋白、血清铁蛋白、红细胞计的数据高于对照组,差异有统计学意义(t=2.581、2.922、6.893,P<0.05),并且观察组总铁结合率数据要比对照组总铁结合率数据要低,两组的总铁结合率结果显示为差异有统计学意义(t=2.081,P<0.05),且在治疗完后两组产妇的各项指标恢复至正常。观察组患者的不良反应数据恶心、呕吐、上腹痛、便秘,例数分别为3、1、1、2,其中总不良反应率为7.0%,胎儿妊娠结局数据有低出生胎儿体质、新生儿窒息、早产、其他数据分别为1、2、1、1,例数分别为胎儿妊娠结局率为5.0%。观察组患者的总不良反应率低于对照组,妊娠结局率高于对照组,差异有统计学意义(χ^2=2.909、1.802,P<0.05)。观察组患者的不良反应及妊娠结局数据明显高于对照组,数据有统计学意义。结论在治疗妊娠合并贫血患者时使用生血宁片和琥珀酸亚铁片进行治疗后,发现两种药物都有优缺点,应结合两种药物治疗妊娠合并贫血,以此提高治疗效果。

Objective The effect of graduated Shengxuening tablets and ferrous succinate tablets on clinical treatment of patients with pregnancy complicated with anemia. Methods The patients with early pregnancy and anemia who were treated in our hospital were selected. The time from January 2017 to January 2018, 200 cases were chosen. The selected subjects were divided into two groups according to the numerical random distribution method: the observation group and the control group, the control group was treated with Shengxuening tablets, and the observation group was treated with ferrous succinate tablets. The improvement of hemoglobin, serum ferritin, red blood cell count and total iron binding rate, situation and adverse reactions and pregnancy outcomes after treatment was observed. Results The data of hemoglobin, serum ferritin and red blood cell meter in the observation group were higher than those in the control group, the difference was statistically significant(t=2.581, 2.922, 6.893, P<0.05), respectively, and the total iron binding rate data of the observation group was combined with the total iron of the control group. The rate data was low, and the total iron binding rate of the two groups showed the difference was statistically significant(t=2.081,P<0.05), and the indicators of the two groups returned to normal after the treatment. The adverse reactions of the patients in the obsewation group were nausea, vomiting, upper abdominal pain, and constipation. The number of cases was 3, 1, 1, and 2, respectively. The total adverse reaction rate was 7.0%. The fetal pregnancy outcome data had low birth physique and neonatal asphyxia premature delivery and other data were 1, 2, 1, and 1, respectively. The number of cases was 5.0% for fetal pregnancy. The total adverse reaction rate of the observation group was lower than that of the control group, and the pregnancy outcome rate was higher than that of the control group. the difference was statistically significant(χ^2=2.909, 1.802,P<0.05). The adverse reactions and pregnancy outcomes of the observation group were significantly higher than the control group, and the data were statistically significant. Conclusion In the treatment of pregnancy with anemia patients with Shengxuening tablets and ferrous succinate tablets for treatment, it is found that both drugs have advantages and disadvantages,should be combined with two drugs to treat pregnancy with anemia, in order to improve the treatment effect.