DNA甲基化动态模式在重编码过程中的作用

Dynamic Models of DNA Methylation in Recoding Process

DNA甲基化作为主要的表观遗传修饰方式在细胞分裂与分化过程中扮演着重要角色。在生殖细胞生成与胚胎的早期发育过程中,DNA甲基化具有动态变化的特征,其动态模式直接影响细胞核重编码程序的,控制胚胎的成活率及发育状况。本文综述了DNA甲基化修饰在核重编程过程中的动态模式、相关酶及甲基化结合蛋白的作用模式等。

DNA methylation has become one of the most important areas in cell division and cell differentiation.In the process of PGC and early embryos,the survival rate of embryo and the embryonic development was controlled principally by methytransferase in DNA methylation and mapping.This paper summarized some important aspects of DNA methylation,including its characteristics and the biological of DNA methylating transferase.