帕金森病血液生物标志物的研究进展

Progress of blood biomarkers in patients with Parkinson’s disease

帕金森病(PD)是仅次于阿尔茨海默病的第二大神经变性疾病,在中老年人群中较常见,其发病率随着年龄的增长而增高。然而在现阶段帕金森病的诊断主要依据患者的临床症状以及医生的自身经验。因此,需要寻找可检测的生物标志物对帕金森病进行诊断和病情进展的跟踪。本文对近年来主要的潜在帕金森病血生物标志物的研究进展进行综述。

Parkinson's disease(PD)is the second largest neurodegenerative disease after Alzheimer's disease,more common in older adults,and its incidence increases with age.However,at the present stage,the clinician diagnose whether patients with PD by patients’symptoms and their own experience.Therefore,it is necessary to look for detectable biomarkers to diagnose the disease and track the disease progress.This article mainly reviews the potential biomarkers of blood source in patients with PD in recent years.