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活化T细胞核因子与肺动脉高压的研究进展 被引量:1

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摘要 活化T细胞核因子(nuclear factor of activated T cell,NFAT)是一类具有多向调节功能的转录因子,最初在活化T细胞的核提取物中发现,结合白细胞介素2(interleukin 2,IL-2)启动子,在免疫应答中诱导基因转录,促进T细胞活化。NFAT在哺乳动物组织细胞中广泛表达,在细胞分化、生长过程中起重要作用。越来越多的研究表明,NFAT和肺动脉高压发病机制密切相关。本文主要针对NFAT在肺动脉高压发生、发展过程中的作用作一综述,为其诊断和治疗提供新思路。
作者 胡肖依 汪涛
出处 《内科急危重症杂志》 2019年第6期504-507,共4页 Journal of Critical Care In Internal Medicine
基金 国家自然科学基金(No:81470252)
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