辅激活因子及组蛋白协同乙酰化修饰对NF-κB亚基转录调控的影响

Effect of Coactivator and Histone Coacetylation on Transcription Regulation of NF-κB Subunit

核因子κB(NF-κB)信号转导通路在细胞的增殖、分化、凋亡、免疫应答及炎症反应中具有重要的调节作用。炎症调节机制极其复杂,NF-κB在不同的环境下,通过不同的翻译后修饰、协同组蛋白共价修饰以及招募辅激活因子参与调控下游靶基因的表达。辅激活因子具有乙酰基转移酶活性,对转录激活的调控至关重要,而组蛋白的乙酰化修饰一直是表观遗传学研究的热点,其可使NF-κB对靶基因的特异性调控更加精确。两者协同作用在NF-κB亚基转录调控中发挥关键作用。

The signal transduction pathway of nuclear factor-κB(NF-κB) plays an important regulatory role in cell proliferation,differentiation,apoptosis,immune response and inflammatory response.The mechanism of inflammatory regulation is extremely complex.In different environments,NF-κB participates in the regulation of downstream target gene expression through different post-translational modification methods and covalent modification of synergistic histones and recruitment of coactivators.Coactivator has the activity of acetyltransferase,which is important for the regulation of transcriptional activation.The acetylation of histones has long been a hot topic in epigenetics,which can make the specific regulation of NF-κB on target genes more precise.The synergistic effect of the two plays a key role in the transcriptional regulation of the NF-κB subunit.