YAP介导的力学信号转导在血管生成中的研究进展

Research Progress of YAP-Mediated Mechanical Signal Transduction in Angiogenesis

皮肤组织工程支架中内皮细胞所感知的机械力是调控其黏附、迁移、血管生成等生物学行为的重要因素。从细胞感知外界力学刺激到基因转录水平发生变化的过程中,细胞骨架和Yes相关蛋白(YAP)发挥重要作用。血管内皮生长因子(VEGF)是血管生成的主要驱动因素,其作用于VEGF受体后能诱导细胞骨架重构并激活YAP的协同转录功能。破坏细胞骨架结构或降低YAP活性可抑制VEGF促进血管生成的作用。因此,细胞骨架和YAP所介导的力学信号转导是血管生成过程中必不可少的调控因素。理解力学信号转导调控内皮细胞形成血管的作用和机制,有助于推动人工支架在皮肤软组织缺损治疗中的应用和发展。

The mechanical force perceived by endothelial cells in scaffolds for skin tissue engineering is an important factor in regulating biological behaviors such as adhesion,migration and angiogenesis.Cytoskeleton and Yes-associated protein (YAP) play an important role in the process from cell perception of external mechanical stimulation to changes in gene transcription level.Vascular endothelial growth factor(VEGF) is a major driver of angiogenesis,which can induce cytoskeletal remodeling and activate the cooperative transcription function of YAP after acting on VEGF receptor.Destruction of cytoskeletal structure or decrease of YAP activity inhibits the role of VEGF in promoting angiogenesis.Therefore, cytoskeleton and YAP mediated mechanical signal transduction are essential regulatory factors in angiogenesis.Understanding the effect and mechanism of mechanical signal transduction in regulating vascular formation of endothelial cells is helpful to promote the application and development of artificial scaffolds in the treatment of soft tissue defects.