神经内分泌异常与帕金森病的相关性

Correlation between Neuroendocrine Abnormalities and Parkinson’s Disease

帕金森病(PD)是一种多见于老年人的神经退行性疾病,以黑质多巴胺能神经元变性、缺失、减少,神经元α-突触核蛋白沉积及路易小体形成为病理特征。神经内分泌异常在PD中较为常见,它与PD的运动和非运动症状相关,具有重要的临床和治疗价值。其中,胃饥饿素(Ghrelin)具有明确的神经保护作用,而不同研究对褪黑素(MLT)和糖皮质激素(GC)与PD的相关性存在争议。因此,PD临床表现与MLT、Ghrelin、GC等神经内分泌激素之间的关系未来需进一步探讨。

Parkinson′s disease(PD) is a neurodegenerative disease mostly seen in the elderly,mainly pathologically characterized by degeneration,deletion and reduction of dopaminergic neurons in the substantia nigra,deposition of α-synuclein in neurons and formation of Lewy body.Neuroendocrine abnormalities are common in PD,which are associated with motor and non-motor symptoms of PD and have great clinical and therapeutic values.Ghrelin has a clear neuroprotective effect,and different studies have controversies on the correlation of melatonin(MLT) and glucocorticoid(GC) with PD.Therefore,the relationship between clinical manifestations of PD and neuroendocrine hormones such as MLT,Ghrelin and GC needs to be further explored in the future.