母体中多肽与子痫前期相关性的研究进展

Advances in Research on Relationship between Polypeptide in Mother and Preeclampsia

子痫前期是一种严重的妊娠期疾病,能引起多种妊娠期并发症,并能导致孕产妇的围生期病死率升高。目前,临床对子痫前期的诊断为监测孕妇的血压和24 h蛋白尿,而唯一有效的治疗方法为及时娩出胎盘,但仍缺乏对子痫前期的特异性诊疗。多肽组学因其便携性和有效性已应用于多种疾病的早期预防、诊断和治疗,且其在子痫前期中的研究也越来越受关注。因此,深入了解与子痫前期相关的多肽,有利于子痫前期发病机制、早期预防以及诊疗的研究。

Preeclampsia is a serious gestational complication,can lead to an increase in perinatal mortality in most maternal women.At present,the clinical diagnosis of preeclampsia is to monitor the blood pressure of pregnant women and 24-hour proteinuria,and the only effective treatment is to timely deliver the placenta,but there is still a lack of specific treatment of the disease.Peptideomics has been applied to the early prevention,diagnosis and treatment of various diseases because of its portability and effectiveness,and its research in preeclampsia has received more and more attention.Therefore,in-depth study of preeclampsia related peptides is conducive to the study of the pathogenesis of preeclampsia and beneficial for the diagnosis and treatment of preeclampsia in the clinic.