慢性疲劳综合征发病机制的研究进展

Research Progress in Pathogenesis of Chronic Fatigue Syndrome

慢性疲劳综合征(CFS)是以慢性疲劳为主要表现的一种疾病。随着社会的进步,CFS的发病率逐年上升,给社会造成了很大的疾病负担。自此病提出至今尚未发现明确的发病机制。CFS病理生理的研究一直是医学界的热点,目前多认为CFS与多系统功能异常相关。通过对免疫功能、神经内分泌系统、能量代谢、大脑功能、认知障碍及基因表达等方面的研究发现,不同学说可以解释CFS患者不同的临床表现,但目前仍缺乏明确的诊断标准和特效的治疗手段。

Chronic fatigue syndrome(CFS) is a disease characterized by chronic fatigue.With the progress of society,its incidence has been increasing year by year,causing a great disease burden to the society.The clear pathogenesis is not identified, and its pathophysiological research has been a hot topic in the medical field,and it is currently believed that CFS is associated with multiple systemic dysfunction.Studies on immune function,neuroendocrine system,energy metabolism,brain function,cognitive impairment and gene expression found that different theories can explain the different clinical manifestations of CFS patients,but there is still no clear diagnostic criteria and special treatments.