血清IL-33水平对动脉粥样硬化性脑梗死患者预后的预测价值

Predictive value of serum interleukin-33 levels in the patients with atherosclerotic cerebral infarction

目的:探究血清IL-33在预测动脉粥样硬化性脑梗死(atherosclerotic cerebral infarction,ACI)患者预后中的应用价值。方法:收集142例ACI患者的临床资料,所有患者入院后行美国国立卫生研究院卒中量表(NIHSS)评分,并采用ELISA法检测血清IL-33水平。在出院90 d后进行改良Rankin量表(mRS)评分,根据mRS评分分为预后良好组(n=69)和预后不良组(n=73),分别对两组患者基线期一般资料和血清学资料进行比较。对NIHSS评分与血清IL-33水平行Pearson相关性分析,并通过Logistic回归分析影响ACI患者预后的因素,绘制血清IL-33水平的ROC曲线。结果:预后不良组年龄、既往脑梗死病史和入院时NIHSS评分明显高于预后良好组(P均<0.05),血清IL-33水平明显低于预后良好组(P<0.01)。血清IL-33水平与入院时NIHSS评分呈负相关(r=-0.581,P<0.01)。入院时NIHSS评分是预后不良的危险因素(P<0.01),而血清IL-33水平是保护因素(P<0.01)。ROC曲线下面积为0.835,敏感性为91.3%,特异性为72.5%。结论:血清IL-33水平降低可作为预测ACI患者预后不良的指标。

Objective:To explore the prognostic value of serum IL-33 in the prediction of the patients with atherosclerotic cerebral infarction(ACI).Methods:A total of 142 patients with ACI were enrolled.Their clinical data and National Institutes of Health Stroke Scale(NIHSS)were collected,and the serum IL-33 level was detected by ELISA before treatment.Modified Rankin Scale(mRS)score was performed 90 days,and the patients were divided into the good prognosis group(n=69)and the poor prognosis group(n=73)according to mRS score.The general baseline data and serological data of the patients in the two groups were compared,respectively.The Spearman correlation between NIHSS score and IL-33 level was analyzed,and Logistic regression was used to analyze the factors which influence the prognosis of the patients with ACI and the ROC curve of serum IL-33 level was further plotted.Results:Age,past history of cerebral infarction and NIHSS score in poor prognosis group were higher than those in good prognosis group(P<0.05),and the serum IL-33 level was significantly lower than those in good prognosis group(P<0.01).IL-33 level was negatively correlated with the NIHSS score at admission(r=-0.581,P<0.01).Higher NIHSS score at admission was a risk factor for poor prognosis(P<0.01),while higher serum IL-33 level was a protective factor(P<0.01).The ROC curve showed that the area under the curve was 0.835,the sensitivity was 91.3%,and the specificity was 72.5%.Conclusion:The decreased serum IL-33 levels could be used as a predictor of poor prognosis for patients with ACI.