高效低毒杀菌剂苯醚甲环唑新工艺研究

Study on New Synthesis Process of Novel Fungicides Difenoconazole

研究了苯醚甲环唑的合成新方法。以间二氯苯为起始原料,经过付克反应、环合、溴化、亲核取代及醚化反应合成苯醚甲环唑。新工艺提高了反应选择性,简化精制过程。该工艺总收率84%,为工业化提供了一条绿色经济的合成路线。

A new synthesis method of difenoconazole was studied.Difenoconazole was prepared from 2,4-dichloroace tophenone by Friedel Crafts reaction,cyclization,bromination,nucleophilic substitution and etherification,The new process improves the selectivity of the reaction and simplifies the purification process.The total yield of this process is 84%,which provides a green and economical synthetic route for industrialization.