不对称二甲基精氨酸对高原性肺动脉高压的影响

Asymmetric Dimethylarginine for High Altitude Pulmonary Hypertension

高原性肺动脉高压是高原性疾病的常见并发症。不对称二甲基精氨酸是一氧化氮合酶的抑制剂,竞争性地抑制一氧化氮的产生,诱发氧化应激反应,引起血管内皮功能不全,在高原性肺动脉高压的发生和发展中起重要作用。现从不对称二甲基精氨酸的来源、代谢及生理功能着手,对其在高原性肺动脉高压发生和发展中的影响做一综述。

High altitude pulmonary hypertension is a common complication of altitude diseases.Asymmetric dimethylarginine is an inhibitor of nitric oxide synthase,which competes to inhibit the production of nitric oxide,induces oxidative stress,causes vascular endothelial insufficiency,which plays an important role on the development of high altitude pulmonary hypertension.This paper starts with the origin,metabolism and physiological function of asymmetric dimethylarginine,and gives a review of its influence on the development of high altitude pulmonary hypertension in the plateau.