环状RNA在冠状动脉粥样硬化性心脏病中的研究进展

CircRNA in Coronary Atherosclerotic Heart Disease

环状RNA(circRNA)是一类与线性RNA不同的非编码RNA,具有microRNA海绵、与蛋白质形成功能复合物、调控亲本基因表达、翻译成蛋白质等作用。早期文献报道了circRNA与肿瘤、糖尿病和神经系统疾病的发生和发展相关,而最新的研究表明circRNA对心血管系统疾病——冠状动脉粥样硬化具有显著影响,并有可能成为新的疾病诊断标志物或新的治疗干预靶点。现主要论述circRNA在冠状动脉粥样硬化性心脏病中的研究与应用。

Circular RNA(circRNA)is a type of non-coding RNA differed from linear RNA,which has the characteristics of multiple functions such as acting as microRNA sponges,forming functional complexes combined with proteins,regulating the expression of parental genes and translating into proteins.Early studies indicated that circRNA was associated with tumor,diabetes and neurological diseases,while latest studies showed that circRNA had a significant impact on coronary atherosclerosis,one of cardiovascular disease,and that it could become either a new diagnostic marker or a novel therapeutic intervention target.Our review mainly discusses the research and application of circRNA in coronary atherosclerotic heart disease.