营养因子对瘦素及其受体基因表达的影响

Effect of Trophic Factors on the Expression of Leptin and Its Receptor Gene

瘦素是由脂肪细胞中的肥胖基因编码的蛋白质类激素,由脂肪组织合成和分泌,作用于下丘脑并发出可用能量储备的信号,进而抑制食欲和食物摄入,增加能量消耗,调节体质量。瘦素基因和瘦素受体在机体能量平衡和脂肪组织沉积中起着重要的调节作用,营养成分可通过多种途径来调控其基因的表达,进而影响机体的代谢过程。本研究就脂肪及脂肪酸、蛋白质及氨基酸、碳水化合物、维生素、矿物质、植物及植物提取物、激素等营养因子对瘦素及其受体基因的表达作用及其调控机制做简要概述。

Leptin is the protein hormone encoded by obese gene in fat cells.It is synthesized and secreted by fat tissue.Leptin acts on the hypothalamus and signals available energy reserves,suppresses appetite and food intake,increases energy expenditure and regulates body weight.Leptin gene and leptin receptors play an important role in energy balance and adipose tissue deposition.Nutrients can regulate gene expression through various ways,and then affect the metabolic process of the organism.We have briefly summarized the effect of nutritional factors such as fat and fatty acids,protein and amino acids,carbohydrate,vitamin,mineral,plant and its extract,hormone on the expression of leptin and its receptor gene and its regulatory mechanism.