江苏省扬州市邗江区青少年尿酸情况及相关因素调查研究

Serum uric acid level and its correlation among adolescents in Hangjiang district of Yangzhou city

目的了解江苏省扬州市邗江区13~16岁青少年高尿酸血症(HUA)患病情况及相关影响因素。方法2018年10月招募扬州市邗江区13~16岁青少年509名,采用Benecheck尿酸分析仪检测青少年空腹血尿酸值,调查问卷收集答卷人的一般信息、家族史、饮食习惯及生活习惯等。采用t检验比较2组间SUA水平差异,采用χ2检验比较2组间HUA发生率;SUA影响因素采用Logistic回归分析。结果扬州市邗江区509名青少年平均血尿酸水平为(374±98)μmol/L,男生为(420±103)μmol/L,高于女生(329±70)μmol/L(t=11.69,P<0.05)。HUA总患病率为36.9%(188/509),男生患病率为43.2%(108/250),高于女生的30.8%(80/259)(χ2=4.16,P<0.05)。多元Logistic回归模型显示男性[OR=1.70,95%CI(1.18,2.45)]、肥胖[OR=8.99,95%CI(4.58,17.63)]、高盐多油饮食[OR=1.67,95%CI(1.05,2.61)]、食用豆制品[OR=2.66,95%CI(1.45,4.88)]、食用动物内脏[OR=7.81,95%CI(3.42,17.83)]、食用水产品[OR=4.80,95%CI(2.83,8.12)]、饮用含糖饮料[OR=6.49,95%CI(3.08,13.64)]、电子产品使用时间[OR=1.98,95%CI(1.07,3.65)]可能是高尿酸血症的危险因素(P<0.05),水果[OR=0.52,95%CI(0.32,0.85)]、户外活动[OR=0.55,95%CI(0.33,0.92)]可能是HUA的保护因素(P<0.05)。结论扬州市邗江区13~16岁青少年血尿酸水平升高明显,男性、肥胖、高盐多油饮食、豆制品、动物内脏、水产品、含糖饮料可能是高尿酸血症的危险因素,水果、户外活动可能是HUA的保护因素,有关部门应采取相应措施进行青少年HUA早期防治。

ObjectiveTo investigate the prevalence of hyperuricemia and its correlation among adolescents aged 13-16 in Hanjiang district of Yangzhou city.MethodsFive hundred and nine adolescents aged 13-16 years in Hangjiang district of Yangzhou city were recruited.Their fasting serum uric acid level were measured by Benecheck premium UA monitoring system.The demographic imformation,family history,eating and living habits of the respondents were collected by questionnaires.ResultsThe average serum uric acid level of 509 adolescents in Hangjiang district of Yangzhou city was(374±98)μmol/L,and(420±103)μmol/L in males,higher than that of females[(329±70)μmol/L](t=11.69,P<0.05).The overall prevalence of HUA was 36.9%(188/509),and 43.2%(108/250)in males,higher than in females 30.8%(80/259)(χ2=4.16,P<0.05).Multivariate Logistic regression analysis showed that male[OR=1.70,95%CI(1.18,2.45)],obese[OR=8.99,95%CI(4.58,17.63)],high-salt oily diet[OR=1.67,95%CI(1.05,2.61)],soy products[OR=2.66,95%CI(1.45,4.88)],animal offal[OR=7.81,95%CI(3.42,17.83)],seafood[OR=4.80,95%CI(2.83,8.12)],sugary drinks[OR=6.49,95%CI(3.08,13.64)]and time spent on electronic products[OR=1.98,95%CI(1.07,3.65)]might be risk factors for hyperuricemia(P<0.05),while fruit[OR=0.52,95%CI(0.32,0.85)]and outdoor activities[OR=0.55,95%CI(0.33,0.92)]might be protective factors for HUA(P<0.05).ConclusionThere is a high prevalence of hyperuricemia among adolescents aged 13-16 in Hangjiang district of Yangzhou city.The level of serum uric acid in adolescents significantly increased.Male,obesity,high salt and oily diets,soy products,animal offal,seafood,and sugary drinks may be risk factors for HUA.Fruits and outdoor activities may be protective factors for HUA.Relevant disciplines can take corresponding measures to prevent adolescent HUA.