我院质子泵抑制剂不合理用药分析

Analysis of Irrational Use of Proton Pump Inhibitors in Our Hospital

目的对我院质子泵抑制剂(PPIs)进行合理用药专项点评并针对结果进行分析,为PPIs临床合理应用提供参考。方法随机抽取我院2018年12月26日~2019年5月25日的门诊处方1000张及出院病历564份,对处方及医嘱用药适宜性进行合理用药评价并进行分析。结果总体不合理用药率为6.7%(门诊和住院分别5.0%与9.8%);PPIs不合用药类型分布:用药指征不适宜占25.7%(28例)、用法用量不适宜占42.2%(46例)、剂型选择不当占12.8%(14例)、疗程过长占9.2%(10例)、联用不当占6.4%(7例)、重复用药占3.7%(4例)。结论我院PPIs的合理使用仍需进一步加强,尤其应严格把握PPIs的预防使用指征、预防使用剂量以及剂型的选择。

OBJECTIVE To evaluate and analyze the rational drug use of proton pump inhibitors(PPIs) in the hospital so as to provide the reference for the clinician. METHODS 1 000 outpatient prescriptions and 564 discharged medical records were randomly sampled from December 26, 2018 to May 25, 2019.The suitability of prescriptions for PPIs use was evaluated and analyzed. RESULTS The overall unreasonable PPIs use rate was 6.7%(5.0% in outpatient and 9.8% in hospital, respectively);Distribution of unsuitable drug use problems:unsuitable indications of medication accounted for 25.7%(28 cases), unsuitable usage and dosage accounted for 42.2%(46 cases), improper dosage form selection accounted for 12.8%(14 cases), excessive course of treatment accounted for 9.2%(10 cases), improper combination accounted for 6.4%(7 cases) and repeated use accounted for 3.7%(4 cases). CONCLUSION The rational use of PPIs should be further strengthened, expecially in the indication, dosage and dosage form.