2013-2018年我院呼吸科药物不良反应106例回顾性分析

Retrospective analysis of 106 adverse drug reactions in respiratory department of our hospital from 2013 to 2018

目的:分析呼吸科药品不良反应(ADR)发生的特点和临床表现,降低临床用药风险。方法:采用回顾性分析方法对呼吸科2013-2018年收集上报的ADR报告106例进行汇总,从患者性别、年龄、药品种类、给药途径、药品剂型、抗菌药物种类、累及系统/器官、报告者等进行统计分析。结果:106例ADR报告中,女性ADR发生率远高于男性;60岁以上患者构成比最高;给药途径中以静脉滴注引起的ADR最多;抗感染药物引起的ADR最多,其中以喹诺酮类最显著;ADR累及的系统/器官损害以皮肤及其附件损害为主;医生为主要上报者。结论:医院应进一步加强ADR监测报告工作,鼓励临床药师发挥自身优势,促进临床合理、安全、有效的使用药物。

Objective:To analyze the characteristics and clinical manifestations of adverse drug reactions(ADR)in respiratory department and reduce the risk of clinical medication.Methods:A retrospective analysis was used to summarize 106 cases of ADR reports collected and reported by the respiratory department from 2013 to 2018.Statistical analysis was carried out from patients'gender,age,drug type,administration route,drug dosage form,antibacterial drug type,involved system/organ,reporter,etc.Results:In 106 ADR reports,the incidence of ADR in women was much higher than that in men,and the proportion of patients over 60 years old was the highest.Among the routes of administration,ADR caused by intravenous drip was the most,the ADR caused by anti-infective drugs was the most.Quinolones were the most common ADR caused by anti infective drugs.ADR-affected system/organ damage was primarily skin and its accessories damage.The doctors were the main reporters.Conclusion:The hospital should further strengthen the ADR monitoring and reporting work,encourage clinical pharmacists to play their own advantages,and promote the clinical rational,safe and effective use of drugs.