锶及海藻酸盐水凝胶在骨组织工程中的研究进展

Research progress of strontium and alginate hydrogel in bone tissue engineering

因炎症、外伤、肿瘤等导致的口腔颌面部骨缺损是常见的骨缺损之一,一直以来都是临床上治疗的难点,给口腔医生带来了重大挑战。目前,骨缺损治疗最有效的是自体骨移植,但存在数量有限、增加患者痛苦等问题。异体骨治疗骨缺损效果也较佳,但异体骨同样存在许多缺点,如免疫排斥、交叉感染等。因此,为了解决骨缺损的治疗难题,骨组织工程应运而生。海藻酸盐具有生物相容性好、可降解等优点,广泛用于骨组织工程;同样锶离子具有促进成骨、成血管的作用,也被广泛应用于骨组织工程。但目前这两者的研究状况没有系统论述,故本文将对锶和海藻酸盐水凝胶在骨组织工程中的研究进行综述。

Oral and maxillofacial bone defects caused by inflammation,trauma,tumors,etc.,are one of the common bone defects,and have always been a difficult point of clinical treatment which provides a major challenge for dentists.At present,the most effective treatment for bone defect is autologous bone transplantation,but there are problems such as limited source and increased patient suffering.Allogeneic bone is also effective in treating bone defects,but allogeneic bones also have many disadvantages,for example immune rejection and cross infection.Therefore,in order to solve the treatment problem of bone defects,bone tissue engineering came into being.Sodium alginate has the advantages of good biocompatibility and biodegradability,and is widely used in bone tissue engineering.Similarly,strontium which is also widely used in bone tissue engineering,has the functions of promoting osteogenesis and angiogenesis.However,there is no systematic discussion on these two aspects.This paper will summarize the research of strontium and alginate hydrogels in bone tissue engineering.