等离子体聚合聚环氧乙烷类涂层用于提高镁合金心血管支架抗腐蚀性能

Plasma Polymerized Poly( Ethylene Oxide)-like Coating for Enhancing Corrosion Resistance of Magnesium Alloy Cardiovascular Stents

本研究以二乙二醇二甲醚(Diglyme)为单体,通过等离子体聚合技术得到均匀、无孔的聚环氧乙烷类(PEO-Like)涂层,并用来提高MgZnMn合金的抗腐蚀性能。在两种放电功率下制得了不同结构的涂层。X射线光电子能谱(XPS)和傅里叶变换衰减全反射红外光谱(ATR-FTIR)显示,高功率下制备的涂层(HPEO)比低功率下制备的涂层(LPEO)分子结构交联度更高。电化学与体外浸泡测试证明两种涂层均具有良好的防腐蚀效果,但HPEO保护效果更佳。经过球囊扩张试验后,HPEO在MgZnMn支架上仍粘附良好,并且在后续的PBS浸泡实验中,涂层依旧能显著降低支架的降解速率。

In this paper,in order to enhance the corrosion-resistance of MgZnMn alloy,plasma polymerization coatings were synthesized by using diethylene glycol dimethyl ether(diglyme)as organic monomer.Two kinds of an ultra-thin,pinhole-free with poly(ethylene oxide)-like(PEO-like)characteristics prepared with two different discharge power.X-ray photoelectron spectroscopy(XPS)and attenuated total internal reflection Fourier transform infrared spectroscopy(ATR-FTIR)results showed that,higher cross-linked structure formed when using high power(HPEO)than low power(LPEO).Electrochemical and in vitro immersion tests showed that two coatings had good anti-corrosion effect,especially the HPEO coating.The HPEO coating adhered well on the MgZnMn stent after the balloon expansion test,and significantly slowed down the degradation rate of the stent in the subsequent in vitro immersion test.