胃食管反流病动物模型研究现状

The current situation of research of gastroesophageal reflux disease

胃食管反流病严重影响人们的健康成为消化系统的主要问题,是一种常见的上消化道动力障碍性疾病,为了找到有效的治疗方法,很多学者投入到胃食管反流病相关的基础与临床实验中。动物模型可以提供胃食管全面的功能及解剖的研究平台,我们探索一种内镜下制备胃食管反流病大体动物模型,为后续胃食管反流病内镜下治疗研究提供更好的帮助。模型制作方法多样,主要分为四种类型:微创法制作动物模型、手术法制作动物模型(包括破坏食管下括约肌、结扎幽门或十二指肠、食管十二指肠或胃肠吻合术等)、外源物质直接灌注及内镜下动物模型的制备,其中各种方法都有其自身的优缺点,可根据不同的研究目的及要求选用不同的方法,制备出合适的动物模型。

Gastroesophageal reflux disease( GERD) has been the one of the main diseases of the digestive system that seriously affected our healthy. GERD is a common upper gastrointestinal dynamic disease. In order to look for the effective method for the treatment of this disease,specialists and scholars has been conducting experimental study on GERD in clinic and basics. Animal models can provide research platform of gastroesophageal anatomic structure and function. It can provide a lot of help in endoscopic treatment of GERD that exploring a way of making GERD animal models. There are a lot of methods to conduct the animal models,those can be divided into four kinds,including minimally invasive procedure,surgery method( for instance destroying LES,Pyloric or duodenal ligation,Gastroenterostomy and the like),pouring acid substance into gastroesophagael and making with endoscope. Each method has own advantages and disadvantages,that can be chose to make appropriate animal modals on the basis of own purpose and requirement.