肠道致病菌鞭毛调节蛋白FlgM功能分析及应用展望

The Application Prospect of Flagellar Associated Protein FlgM as Fusion Protein

鞭毛作为细菌最主要的运动器官,可通过促进细菌黏附、定植和侵袭以及生物被膜(Biofilm)的形成来影响细菌的毒力和耐药性。而鞭毛的组装合成涉及50多种蛋白质,FlgM蛋白作为持续控制器可调节其他鞭毛相关基因的转录水平,从而影响鞭毛的长度和数量等因素,进而影响细菌的毒力。此外,FlgM属于可溶性蛋白具备特有的C末端不稳定性结构,被视为潜在的融合蛋白。本综述依据已有研究详述了FlgM蛋白结构及功能,为深入探究与鞭毛相关的致病机制及其作为融合蛋白的应用前景途径提供理论支撑。

Flagella as the main movement organ of bacteria can influence the virulence of bacteria by promoting bacterial adhesion, colonization and invasion. The assembly and synthesis of flagella involve more than 50 proteins, Regulatory protein FlgM as continuous controller to regulate the transcription levels of other flagellate-related genes, thereby affecting factors such as the length and number of flagella, which in turn affects the virulence of bacteria. In addition, FlgM has a characteristic c-terminal structure and is considered a potential fusion protein., This review provides detailed theoretical support for the structure and function of FlgM protein,and based on existing researches, in order to further explore its pathogenic mechanism related to flagella and its application as a fusion proteins.