肺炎支原体肺炎患儿血清维生素D水平及其对免疫功能的影响

Serum Vitamin D Levels in Children with Mycoplasma Pneumoniae Pneumonia and Its Effects on Immune Function

目的:探讨肺炎支原体肺炎(MPP)患儿血清维生素D(Vit D)水平及其对免疫功能的影响。方法:选择2016年1月至2017年1月我院儿科确诊的MPP患儿100例作为MPP组,另选同期体检的健康儿童100例作为对照组,检测两组儿童血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4及T淋巴细胞亚群水平,并按照病情严重程度将MPP组分为轻症组和重症组进行分层分析。结果:MPP组患儿的血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4、CD3^+、CD4^+、CD4^+/CD8^+水平均低于对照组(P均<0.01);两组患儿CD8+水平比较差异无统计学意义(P>0.05)。重症组患儿血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4、CD3^+、CD4^+、CD4^+/CD8^+水平均低于轻症组,CD8^+水平高于轻症组(P均<0.01)。结论:MPP患儿的血清25-(OH)D3水平降低,免疫功能指标水平降低,监测血清25-(OH)D3水平及免疫功能水平可为临床治疗提供指导。

Objective:To probe into the changes of serum vitamin D(Vit D)levels in children with Mycoplasma pneumoniae pneumonia(MPP)and its effects on immune function.Methods:A total of 100 MPP children diagnosed in pediatrics in our hospital from Jan.2016 to Jan.2017 were selected as the MPP group,and 100 healthy children were selected as the control group.Serum levels of 25-(OH)D3,IgM,IgA,IgG,complement C3,complement C4 and T lymphocyte subsets were detected in two groups.The MPP group was divided into the mild group and the severe group according to the severity of the disease.Results:The levels of 25-(OH)D3,IgM,IgA,IgG,complement C3,complement C4,CD3^+,CD4^+,CD4^+/CD8^+ in the MPP group were lower than those in the control group(P<0.01),and there was no significant difference in levels of CD8^+ between two groups(P>0.05).Serum levels of 25-(OH)D3,IgM,IgA,IgG,complement C3,complement C4,CD3^+,CD4^+,CD4^+/CD8^+ in the severe group were lower than those in the mild group,and the levels of CD8^+ were higher than those in the mild group(P<0.01).Conclusion:The serum levels of 25-(OH)D3 and indicators of immune function are decreased in MPP children.The monitoring on serum levels of 25-(OH)D3 and immune function can provide guidance for clinical treatment.