RNA IncWDR 26表达水平与肝癌患者疾病进展和预后的相关性

Correlation between Expression Level of IncWDR 26 and Disease Progression and Prognosis of Liver Cancer Patients

目的:探究RNA IncWDR 26表达水平与肝癌患者疾病进展和预后的相关性。方法:选取2016年1月—2017年1月在我院诊断及治疗的肝癌患者142例,检测患者肿瘤组织及非肿瘤组织中IncWDR 26表达水平,并根据水平高低分为高水平组(71例)及低水平组(71例),对比两组一般资料、无进展生存期、总生存期,使用Kaplan-Meier法绘制生存曲线,应用Log rank检验计算风险比。结果:142例患者肿瘤组织中平均IncWDR 26水平为0.12±0.47(log10),非肿瘤组织中平均IncWDR 26水平为0.21±0.51(log10),肿瘤组织显著低于非肿瘤组织(t=3.093,P=0.002);高水平组在肿瘤直径≤5cm、BLCL分期A期人数比例显著高于低水平组(P均<0.05);两组中位EFS时间分别为23(16~24)个月、18(16~24)个月,高水平组疾病进展风险显著低于低水平组(HR=0.645,95%CI:0.418~0.996,P=0.036),低水平组中位OS时间为22(18~24)个月,高水平组死亡风险显著低于低水平组(HR=0.509,95%CI:0.310~0.834,P=0.006)。结论:IncWDR 26表达水平与肝癌患者疾病进展及预后有显著联系,水平越高预后越好。

Objective:To explore the correlation between expression level of IncWDR 26 and disease progression and prognosis of liver cancer patients.Methods:From January 2016 to January 2017,142 cases of liver cancer patients diagnosed and treated in our hospital were selected,the expression level of IncWDR 26 in tumor tissues and non-tumor tissues of each patient was detected,the patients were divided into high level group(71 cases)and low level group(71 cases).General data,progression-free survival and total survival were compared between the two groups,Kaplan-meier method was used to draw the survival curve,and risk ratio were compared by Log rank test.Results:The average level of IncWDR 26 in the tumor tissue of 142 patients was 0.12±0.47(log10),non-tumor tissues was 0.21±0.51(log10),the level in tumor tissue was significantly lower than non-tumor tissue(t=3.093,P=0.002),the number of patients in high level group with tumor diameter≤5cm and BLCL stage A was significantly higher than that low level group(P<0.05),the median EFS time of the two groups was 23(16~24)months and 18(16~24)months,the risk of disease progression was significantly lower in the high level group than low level group(HR=0.645,95%CI:0.418~0.996,P=0.036),the median OS time in the low level group was 22(18~24)months,and the risk of death in the high level group was significantly lower than low level group(HR=0.509,95%CI:0.310~0.834,P=0.006).Conclusion:The expression level of IncWDR 26 was significantly associated with the progression and prognosis of liver cancer,higher the level and the better prognosis.