硫化氢及硫化氢与细胞内钙离子关系的研究概况

General situation of research on hydrogen sulfide and its relation with intracellular calcium ions

硫化氢作为一种新型的气体信号分子,广泛参与机体各个系统的生理活动。硫化氢能够通过改变细胞内钙离子的浓度对细胞的功能状态产生一定影响。表皮细胞内存在胱硫醚-γ-裂解酶和胱硫醚-β-合酶体系,烧伤应激会抑制大鼠表皮细胞内硫化氢/胱硫酶-γ-裂解酶体系功能,使硫化氢生成减少。严重烧伤应激使多种脏器出现功能障碍,同时再灌注损伤促使机体产生大量氧自由基。各种酶类的激活、炎性因子的释放可加重细胞的水肿,在细胞内发生钙离子超载。因此研究硫化氢对于表皮细胞的作用机制,进一步探究硫化氢在表皮细胞内是否通过钙离子介导信号转导途径具有重要意义。本文对现有国内外关于硫化氢及硫化氢与细胞内钙离子关系的研究进行总结,旨在丰富硫化氢功能研究的理论基础,研究硫化氢与胞内钙离子浓度的相关性从而探讨钙离子是否在硫化氢胞内的信号通路中发挥一定的作用。

Hydrogen sulfide,as a new type of gas signaling molecule,is widely involved in the physiological activities of various systems of the body.Hydrogen sulfide can change the concentration of calcium ions in cells and have a certain effect on the functional state of cells.In epidermal cells,there are systems of cystethioether-γ-lyase and cystethioether-β-synthase.Burn stress can inhibit the function of hydrogen sulfide/cystethioether-γ-lyase system in rat epidermal cells and reduce hydrogen sulfide production.Severe burn stress caused the dysfunction of various organs.And the reperfusion injury caused the body to produce a large amount of oxygen free radicals at the same time.The activation of various enzymes and the release of inflammatory factors can aggravate the edema of cells,and calcium ion overload occurs in the cells.Therefore,it is of great significance to study the mechanism of action of hydrogen sulfide on epidermal cells,and to further explore whether hydrogen sulfide is mediated by calcium ions in epidermal cells.This paper summarizes the current domestic and foreign studies in order to enrich the theoretical basis of hydrogen sulfide function research,study the correlation between hydrogen sulfide and intracellular calcium ion concentration to explore calcium ions whether it plays a certain role in the intracellular signal pathway of hydrogen sulfide.