非编码RNA调控人牙周膜干细胞成骨向分化的研究进展

Progress in research of non-coding RNAs in osteogenic differentiation of human periodontal ligament stem cells

牙周炎是一种常见的炎症性疾病,以牙齿支持结构的进行性损伤为特点,是我国成人牙齿丧失的主要原因。治疗牙周炎的目的不仅是通过控制炎症来阻止疾病发展,更重要的是获得牙周再生。人牙周膜干细胞具有成骨向分化潜能,有望在牙周组织修复再生的临床应用上发挥重要作用。非编码RNA(ncRNA)一般是指不编码蛋白质的RNA。伴随高通量检测技术的不断发展,发现了大量的种类丰富的ncRNA,其生物学功能也被不断揭示。越来越多证据显示,ncRNA在分子机制及细胞组织层面对疾病的发生、发展起重要调控作用,因此探索ncRNA调控机制可为牙周再生的研究提供新思路。本综述主要阐述了目前研究较多的几种ncRNA在人牙周膜干细胞成骨向分化中的调控机制。

Periodontitis is a common inflammatory disease that is characterised by progressive damage to dental supporting structure.Periodontitis is the main cause of tooth loss in adults in China.The aim of periodontal treatment is not only to control inflammation and prevent disease development but also to obtain periodontal regeneration.Human periodontal ligament stem cells(PDLSCs),which are capable of osteogenic differentiation,are expected to play important roles in clinical application of periodontal tissue repair and regeneration.Non-coding RNAs(ncRNAs)generally refer to RNAs that do not encode proteins.The continuous development of high-throughput detection techniques has allowed the identifi cation of a large number of ncRNAs and their biological functions.Increasing numbers of ncRNAs have been reported to function in the pathogenesis of diseases at molecular and cellular levels.Therefore,research on ncRNAs can provide new insights into periodontal regeneration.This review focuses on the regulatory mechanism of several ncRNAs in the osteogenic differentiation of human PDLSCs.