MC法模拟硼中子俘获疗法在肺癌组织剂量分布

Study on Dose Distribution of Boron Neutron Capture Therapy in Lung Cancer Tissue by MC Method

采用国际通用的人体MIRD模型,利用 MCNP模拟肿瘤细胞内发生 BNCT反应后热中子剂量在肿瘤细胞内的分布.用多个模型进行模拟,研究发现当组织成分一定时,中子通量决定了该组织内沉积的有效剂量.且有效剂量大部分沉积在肺癌组织中,正常组织中仅有少量沉积,避免了其他传统治疗方法副作用较大的缺点.

In this paper,we use MCNP to simulate the distribution of thermal neutron dose in tumor cells after BNCT reaction in human MIRD model.It is found that the effective dose of deposition in the tissue is determined by the neutron flux when the composition of the tissue is constant.Most of the effective dose was deposited in lung cancer tissues,and only a small amount was deposited in normal tissues,which avoided the side effects of other traditional treatment methods.