某院128株肺炎链球菌的临床分布及耐药性分析

Clinical Distribution and Drug Resistance of 128 Strains of Streptococcus pneumoniae in a Hospital

目的:探讨大理大学第一附属医院128株肺炎链球菌(SPN)的临床分布及耐药性情况,为临床用药提供更可靠的依据。方法:回顾性分析大理大学第一附属医院2017年3月至2018年3月临床分离128株SPN的临床分布及药敏试验结果情况,采用MIC法进行药敏分析,用WHONET 5.6软件进行数据处理及分析。结果:128株SPN主要来源于痰标本(89.06%),主要来源科室为儿科(53.90%),易感人群主要是婴幼儿(39.06%)和老年人(25.00%)。SPN对青霉素耐药率为33.59%,对红霉素、四环素及甲氧芐氨嘧啶/磺胺甲恶唑的耐药率较高均超过70%;对左氧氟沙星、氧氟沙星、氯霉素、头孢噻肟和阿莫西林敏感率均超过80%;未检出耐万古霉素、厄他培南、莫西沙星、利奈唑胺、泰利霉素菌株。结论:SPN感染好发于婴幼儿及老年人,临床医生应根据药敏试验结果合理、适量选用抗生素,减少SPN耐药菌株的产生。

Objective:The clinical distribution and drug resistance of 128 strains of Streptococcus pneumoniae(SPN)were investigated in the First Affiliated Hospital of Dali University in order to provide more reliable basis for clinical medication.Methods:The clinical distribution and drug sensitive tests of 128 strains of SPN were retrospectively analyzed from March 2017 to March 2018 in the First Affiliated Hospital of Dali University.MIC value was used to analyze the drug sensitivity,and WHONET 5.6 software was used for statistic analysis.Results:128 strains of SPN were mainly found from the Department of Pediatrics(53.90%),and mainly from sputum specimens(89.06%).The susceptible population was mainly infants(39.06%)and elderly(25.00%).The drug resistance rate of SPN to penicillin was 33.59%,and the drug resistance rate of erythromycin,tetracycline and trimethoprim/sulfamethoxazole were more than70%.SPN has higher sensibility to levofloxacin,ofloxacin,chloramphenicol,cefotaxime and amoxicillin with rate of more than 80%.No vancomycin,ertapenem,moxifloxacin,rina thiazole amine and telithromycin drug resistant strain was found.Conclusion:The SPN was mainly isolated from infants and the senior people.More attention should be paid to the result of the drug sensibility to direct clinical rational and moderate use of antibiotics for patients in order to reduce production of SPN drug-resistant strains.