左西孟旦治疗缺血性心肌病急性失代偿性心力衰竭的疗效分析

Analysis of the Effects of Levosimendan on Acute Decompensated Heart Failure of Ischemic Cardiomyopathy

目的:探讨左西孟旦对缺血性心肌病急性失代偿性心力衰竭心功能指标、脑钠肽(BNP)及肌酐水平的影响。方法:纳入我院2016年1月~2018年12月收治的因缺血性心肌病而发生急性失代偿性心力衰竭患者60例,随机分为观察组(n=30)和对照组(n=30)。对照组采用常规治疗,观察组在此基础上联合左西孟旦治疗。收集并分析两组患者心功能相关指标、BNP、肌酐及治疗过程中出现的不良反应情况。结果:观察组临床总有效率为93.33%(28/30),高于对照组63.33%(19/30),差异具有统计学意义(P<0.05);观察组LVEDD、LVESD及心率均低于对照组,差异具有统计学意义(P<0.05);观察组LVEF水平高于对照组,差异具有统计学意义(P<0.05);观察组治疗后BNP水平低于对照组,差异具有统计学意义(P<0.05);两组治疗后肌酐水平差异无统计学意义(P>0.05);观察组不良反应发生率为10.00%(3/30)与对照组16.67%(5/30)差异无统计学意义(P>0.05)。结论:左西孟旦可改善缺血性心肌病急性失代偿性心力衰竭患者心肌收缩力,不良反应发生率低,值得临床推广。

Objective:To investigate the effects of levosimendan on cardiac function,BNP and creatinine levels in patients with acute decompensated heart failure(ACHF)of ischemic cardiomyopathy.Methods:60 patients with acute decompensated heart failure due to ischemic cardiomyopathy admitted to our hospital from January 2016 to December 2018 were randomly divided into observation group(n=30)and control group(n=30).The control group was treated with routine treatment,while the observation group was treated with levosimendan.Cardiac function indexes,BNP,creatinine and adverse reactions were collected and analyzed.Results:The total clinical effective rate in the observation group was 93.33%(28/30),which was higher than that in the control group 63.33%(19/30;P<0.05).The LVEDD,LVESD and heart rate of the observation group were lower than those of the control group(P<0.05).The level of LVEF in the observation group was higher than that in the control group(P<0.05).There was no significant difference in creatinine level between the two groups after treatment.After treatment,the BNP level in the observation group was lower than that in the control group(P<0.05).The incidence of adverse reactions was 10.00%(3/30)in the observation group and 16.67%(5/30)in the control group,whichholds no statistical difference.Conclusion:Levosimendan can improve myocardial contractility in patients with acute decompensated heart failure of ischemic cardiomyopathy,and the incidence of adverse reactions is low,which deserves further clinical application.