具核梭杆菌与结直肠癌相关性的研究进展

Research progress on the relationship between fusobacterium nucleatum and colorectal cancer

结直肠癌(CRC)具有高发病率及死亡率,具核梭杆菌(Fn)与CRC发生发展及耐药性关系密切,但作用机制尚不明确,本文拟从炎症、免疫、表型遗传、代谢、耐药等途径对机制进行探讨。此外,Fn还可作为新型生物标志物用于CRC的临床诊断中,粪便检测、血清学检测、电喷雾电离质谱检测等极具临床诊断价值。同时,针对Fn的抗生素治疗及疫苗治疗为CRC治疗提供了新方向。本文拟Fn导致CRC发生发展及耐药机制、诊断价值、治疗方式进行综述。

Colorectal Cancer(CRC)has high incidence and mortality.Fusobacterium nucaleatum(Fn)is closely related to the occurrence,development and drug resistance of CRC,however,the mechanism is not clear.This paper intends to explore mechanisms from inflammation,immunity,phenotypic inheritance,metabolism,drug resistance and so on.Moreover,Fn can also be used as a new biomarker in the clinical diagnosis of CRC,while fecal test,serological test and electrospray ionization mass spectrometry are of great value in clinical diagnosis.At the same time,antibiotic treatment and vaccine therapy for Fn provide a new direction for the treatment of CRC.This article reviews the mechanism of pathogenesis,drug resistance,the diagnostic value and the treatment of CRC caused by Fn.