基质金属蛋白酶9和血管内皮生长因子对缺血性脑卒中的影响

Effect of matrix metalloproteinase-9 and vascular endothelial growth factor on ischemic stroke

基质金属蛋白酶9(MMP-9)通过促进炎性反应加重缺血性脑卒中(脑梗死)的发展,对疾病预后不利。血管内皮生长因子(VEGF)有利于缺血灶和半暗带血管侧支循环的建立,在脑梗死损伤修复中相对有利。但是MMP-9和VEGF又有着复杂的相互作用,疾病发生时二者浓度的变化可能协同加剧缺血脑组织的损害。本文就近年来对MMP-9和VEGF在脑梗死发展过程中的作用及二者的相互影响做一综述,提出在脑梗死发生后及时降低MMP-9浓度并适时促进VEGF含量可能对预后更有利。

Matrix metalloproteinase 9(MMP-9)can aggravate the development of ischemic stroke(brain infarction)disease by promoting inflammatory response,which is detrimental to the prognosis of the disease.Vascular endothelial growth factor(VEGF)is beneficial to the establishment of ischemic and penumbra collateral circulation,and plays a relatively beneficial role in the repair of brain infarction injury.However,MMP-9 and VEGF have complex interactions,and the changes in concentration at the time of disease may synergistically aggravate the damage of ischemic brain tissue.In this paper,the role of MMP-9 and VEGF in the development of brain infarction and the interaction between them are reviewed in recent years.It is proposed to reduce the concentration of MMP-9 in time after brain infarction,and timely promotion of VEGF content may be more favorable for prognosis.