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开展光刺激治疗癫痫的研究 被引量:2

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摘要 癫痫(Epilepsy,EP)是神经系统常见病,是全球重大健康问题,影响人口超过5000万[1]。我国总体癫痫患病约有900万,其中活动性癫痫患者约600万,每年新增约40万[2]。目前癫痫治疗仍以药物为主,近年来临床使用的10余种新一代抗癫痫药物(antiepileptic drugs,AEDs)主要用于控制癫痫发作症状,整体治疗状况并未明显改善,约有30%的患者对AEDs不敏感,成为药物难治性癫痫(drug resistant epilepsy,DREP)[3]。
出处 《中风与神经疾病杂志》 CAS 2020年第2期187-189,共3页 Journal of Apoplexy and Nervous Diseases
基金 国家自然科学基金(81771396、81801284) 吉林省自然科学基金(白求恩专项)(20180101159JC)。
关键词 癫痫 Epilepsy
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  • 1Scott R C. Status epilepticus in the developing brain: Long term effects seen in humans[J].Epilepsia,2009,50(Suppl. 12): 32- 33.
  • 2Raspall-Chaure M,Chin R F,Neville B G,et al. Outcome of paedi atric convulsive status epilepticus: a systematic review[J]. Lancet Neurol,2006, 5:769-779.
  • 3Scott R C, King M D, Gadian D G,et al. Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes[J].Epilepsia,2006, 47:1493-1498.
  • 4Provenzale J M, Barboriak D P, VanLandingham K,et al. Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial lemporal sclerosis[J].AJR Am J Roentgenol,2008, 190:976-983.
  • 5Sugai K. Treatment of convulsive status epilepticus in infants and young children inJapan[J]. Acta Neurol Scand Suppl,2007,186: 62 -70.
  • 6Yoong M,Chin R F M and Scott R C. Management of convulsive status epilepticus in children[J]. Arch Dis Child Educ Pract Ed, 2009,94: 1-9.
  • 7Singh R K,Gaillard W D. Status Epilepticus in Children[J].Curr Neurol Neurosci Rep,2009, 9: 137-44.
  • 8Treatment of convulsive status epileptieus : recommendations of the Epilepsy. Foundation of America's Working Group on Status Epileptieus[J]. JAMA,1993, 270:854-859.
  • 9Millikan D, Rice B, Silbergleit R. Emergency Treatment of Status Epilepticus: Current Thinking. Emerg Med Clin N Am 2009; 27: 101-113.
  • 10Kailviginen R, Eriksson K, Parviainen I. Refractory generalised convulsive status epilepticus : a guide to treatment[J].CNS Drugs, 2005,19(9) :759-768.

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