糖尿病合并心房颤动的相关研究进展

Research Progress in Diabetes Mellitus Patients with Atrial Fibrillation

糖尿病是一类以高血糖为特征的代谢性疾病,长期存在的高血糖可导致心血管、神经等多脏器系统的功能障碍。心房颤动在糖尿病患者中的患病率高于一般人群。糖尿病患者心房颤动易感性增加的机制目前认为与心房的结构重构、电重构和自主神经重构有关。因其卒中事件高发生率,抗凝治疗是日常管理的基石,但出血风险也随之增加。血糖控制是糖尿病合并心房颤动患者上游治疗中降低心房颤动发生率和减少射频导管消融术后复发的关键因素。

Diabetes mellitus is a metabolic disease characterized by hyperglycemia,which can lead to dysfunction of cardiovascular,nervous and other organ systems. The prevalence of atrial fibrillation in patients with diabetes mellitus is higher than the general population.The mechanisms of increased susceptibility to atrial fibrillation in diabetes mellitus patients are thought to involve electrical,structural and autonomic remodeling in the atrium. Due to its high incidence of stroke events,anticoagulation therapy is the core measure in preventing stroke,but the risk of bleeding also increases. Glycemic control is the key factor in reducing the incidence of atrial fibrillation during upstream therapies and the recurrence after radiofrequency catheter ablation in diabetes mellitus patients with atrial fibrillation.