炎症信号与心房颤动

Inflammatory Signals Associated with Atrial Fibrillation

心房颤动是病理生理学机制复杂的一种心律失常。大量的实验和临床资料表明,心房重构的病理生理学与炎症密切相关。心房重构和炎症之间的联系机制复杂,而不同的潜在疾病和条件均可能影响这些通路。炎症标志物与心房颤动的发生和发展以及射频导管消融术后复发有关。但最常用的抗炎药,如糖皮质激素,增加了感染、出血和高血糖的风险。另外抑制的治疗方法,如细胞因子,又严重干扰正常的心肌功能,在这种情况下,开发特定的抗炎干预措施似乎更具有挑战性和复杂性。这篇综述简要概述了心房颤动与C反应蛋白、肿瘤坏死因子-α、转化生长因子、白介素-6、白介素-10和白介素-37之间的相关性,以及探讨可能用于通过减轻炎症反应预防或治疗心房颤动的药物、减少心房颤动的危险因素和改变生活方式等方法作为上游治疗思路。

Atrial fibrillation is a kind of arrhythmia with complex pathophysiological mechanism. A large number of experimental and clinical data show that the pathophysiology of atrial remodeling is closely related to inflammation. The mechanism of association between atrial remodeling and inflammation is complex,and different underlying diseases and conditions may affect these pathways. Inflammatory markers are associated with the development of atrial fibrillation and recurrence after radiofrequency catheter ablation. But the most commonly used anti-inflammatory drugs,such as glucocorticoids,increase the risk of infection,bleeding and high blood sugar. In addition,inhibitory therapies,such as cytokines,severely interfere with normal cardiac function,in which case the development of specific anti-inflammatory interventions seems to be more challenging and complex. This review provides a brief overview of the association between atrial fibrillation and C-reactive protein,tumor necrosis factor-α,transforming growth factor,interleukin-6,interleukin-10 and interleukin-37. This review also explores the drugs that may be used to prevent or treat atrial fibrillation by reducing inflammatory response,reducing risk factors of atrial fibrillation,changing lifestyle and other methods as upstream treatment ideas.