摘要
越来越多的证据表明,肠道菌群结构紊乱与心血管疾病的发生密切相关。氧化三甲胺作为肠道菌群的代谢产物,在心血管疾病的发生和发展中起重要作用。现就氧化三甲胺与冠心病、心力衰竭、高血压、心房颤动和心肌纤维化的关系及其可能的机制做一综述,为心血管疾病的防治提供新靶点。
More and more evidences show that intestinal flora disorders are closely related to the occurrence of cardiovascular diseases. Trimethylamine oxide, as the metabolite of intestinal flora,plays an important role in the occurrence and development of cardiovascular diseases. This article reviews the relationship between trimethylamine oxide and coronary heart disease,heart failure,hypertension,atrial fibrillation and myocardial fibrosis,and its possible mechanism,so as to provide a new target for the prevention and treatment of cardiovascular diseases.
作者
张琪
宋晓鹏
任茂佳
吴广
赵兴胜
ZHANG Qi;SONG Xiaopeng;REN Maojia;WU Guang;ZHAO Xingsheng(Baotou Medical College,Inner Mongolia University of Science and Technology,Inner Mongolia Clinical Medical College,Hohhot 010017,Inner Mongolia,China;Inner Mongolia Clinical Medical College,Inner Mongolia Medical University,Hohhot 010017,Inner Mongolia,China;Heart Center,Inner Mongolia People's Hospital,Hohhot 010017,Inner Mongolia,China)
出处
《心血管病学进展》
CAS
2020年第1期81-84,共4页
Advances in Cardiovascular Diseases
基金
内蒙古自治区自然科学基金项目(2018MS08065)
关键词
氧化三甲胺
心血管疾病
肠道菌群
Trimethylamine oxide
Cardiovascular diseases
Intestinal flora
