摘要
报道了一种铁催化的酮类化合物的脱氧硼化反应,通过该方法制备一系列的非末端偕二硼化合物,并进一步将该方法应用到克级规模制备中.同时,以常用有机溶剂丙酮为原料制备了相应的非末端偕二硼化合物,并对该偕二硼化合物的C-B键进行选择性单官能团或双官能团化,以验证该类化合物在有机合成中的应用价值.
An iron catalyzed deoxygenative diborylation of ketones to access a variety of internal gem-diboronates has been developed. A scale-up synthesis of such gem-diboronates is also applicable under this condition. Meanwhile, common organic solvent acetone was used as start material to synthesize corresponding internal gem-diboronate, and further mono-or di-functionalization of such internal gem-diboronate has also been explored to demonstrate the synthetic potential of internal gem-diboronates.
作者
何泽瑜
范敏
徐佳能
胡越
王露
吴旭东
夏春谷
刘超
He Zeyu;Fan Mina;Xu Jia'neng;Hu Yue;Wang Lu;Wu Xudong;Xia Chungu;Liu Chao(State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,L anzhou 730000;University of Chinese Academy of Sciences,Beijing 100049;Department of Chemistry and Chemical Engineering,Yibin University,Yibin,Sichuan 644007)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第12期3438-3445,共8页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.91745110,21673261,21603245,21633013,21703265,21872156,21802150)
the Natural Science Foundation of Jiangsu Province(Nos.BK20181194,BK20180247)
the Young Elite Scientist Sponsorship Program by China Association for Science and Technology(No.YESS20170217)
the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2018458)~~
关键词
铁催化
烷基酮
脱氧硼化
偕二硼化合物
iron catalysis
aliphatic ketone
deoxygenative borylation
gem-diboronate
