一种β,β,β-二氟碘-1-苯基乙醇类化合物的简便合成方法

A Convenient Synthesis of β,β-Difluoro-β-iodo-1-phenylethan-1-ols

以二氟碘代丙酮类化合物为原料,利用硼氢化钠选择性还原得到高产率的二氟碘代醇类化合物.该合成方法具有反应条件温和,操作简单,产率高等特点,为合成更多的二氟取代醇类化合物试剂提供了简便的途径.

The synthesis of α,α,α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH4 in methanol at 0 ℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.