蛋白琥珀酸铁对缺铁性贫血患儿血清铁代谢指标及血红蛋白水平的影响

Effect of protein succinate on serum levels of SF,Hb and SI in children with iron deficiency anemia

目的观察蛋白琥珀酸铁对缺铁性贫血患儿血清铁蛋白(SF)、血红蛋白(Hb)及血清铁(SI)水平的影响。方法选择2017年3月至2018年3月盘锦市双台子区卫生健康服务中心治疗的96例IDA患儿,依据随机数字表法分为观察组与对照组,各48例。对照组接受硫酸亚铁治疗,观察组接受蛋白琥珀酸铁治疗。观察两组临床疗效、铁代谢指标(SF、SI)、Hb水平及不良反应。结果观察组总有效率(95.83%)高于对照组(83.33%),不良反应发生率(2.08%)低于对照组(16.67%),差异有统计学意义(P<0.05);治疗前两组SF、SI及Hb水平对比,差异无统计学意义;治疗后观察组SF(39.97±8.06)μg/L、SI(17.30±3.16)μmol/L及Hb(128.69±6.81)g/L高于对照组(31.25±5.78)μg/L、(13.49±2.82)μmol/L、(109.52±7.57)g/L,差异有统计学意义(P<0.05)。结论IDA患儿接受蛋白琥珀酸铁治疗有助于改善SF、SI、Hb水平,消除患儿贫血症状,在提升IDA治疗效果外,且不良反应少。

Objective To observe the effects of iron succinate on serum ferritin(SF),hemoglobin(Hb)and serum iron(SI)levels in children with iron deficiency anemia.Methods 96 children with IDA who were treated by the Health and Medical Service Center of Shuangtaizi District,Panjin City from March 2017 to March 2018 were randomly divided into two groups,with 48 cases in each group.The control group received ferrous sulfate treatment and the observation group received iron protein succinate treatment.The clinical efficacy,iron metabolism index(SF,SI),Hb level and adverse reactions were observed.Results The total effective rate of the observation group(95.83%)was higher than that of the control group(83.33%).The incidence of adverse reactions(2.08%)was lower than that of the control group(16.67%).The difference was statistically significant(P<0.05).There was no significant differences in the levels of SF,SI and Hb between the two groups.After treatment,the SF(39.97±8.06)μg/L,SI(17.30±3.16)μmol/L and Hb(128.69±6.81)g/L were observed higher than the control group(31.25±5.78)μg/L,(13.49±2.82)μmol/L,(109.52±7.57)g/L,the difference was statistically significant(P<0.05).Conclusion The treatment of children with IDA with iron succinate helps to improve the levels of SF,SI and Hb,eliminate the symptoms of anemia in children,and improve the effect of IDA treatment,and has fewer adverse reactions.