胸腺肽联合盐酸溴己新治疗老年慢性阻塞性肺疾病继发肺部感染的临床效果

Clinical effect of Thymosin combined with Bromhexine Hydrochloride in the treatment of pulmonary infection secondary to chronic obstructive pulmonary disease in elderly patients

目的探讨联合应用胸腺肽与盐酸溴己新治疗老年慢性阻塞性肺疾病(COPD)继发肺部感染的临床效果。方法选取2017年10月~2018年10月我院收治的78例COPD患者作为研究对象。采用随机数字表法将其分为两组,每组各39例。对照组患者采用盐酸溴己新治疗,分析组患者采用胸腺肽联合盐酸溴己新治疗。比较两组患者的临床治疗总有效率、不良反应发生情况、肺功能指标[1秒用力呼气量(FEV1)、1秒用力呼气量/用力肺活量(FEV1/FVC)]及血气分析指标[动脉血二氧化碳分压(PaCO2)、血氧分压(PaO2)]。结果分析组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05);治疗后,分析组患者的FEV1、FEV1/FVC高于对照组,差异有统计学意义(P<0.05);治疗后,分析组患者的PaO2高于对照组,差异有统计学意义(P<0.05);治疗后,分析组患者的PaCO2低于对照组,差异有统计学意义(P<0.05)。结论对老年COPD继发肺部感染患者联合应用胸腺肽与盐酸溴己新进行治疗,可更有效地促进患者康复,值得临床应用。

Objective To investigate the clinical effect of Thymosin combined with Bromhexine Hydrochloride in the treatment of pulmonary infection secondary to chronic obstructive pulmonary disease(COPD)in the elderly patients.Methods A total of 78 patients with COPD admitted to our hospital from October 2017 to October 2018 were selected as the study objects.They were divided into two groups by random number table method,with 39 cases in each group.The control group was treated with Bromhexine Hydrochloride,and the analysis group was treated with Thymosin combined with Bromhexine Hydrochloride.The total effective rate of clinical treatment,occurrence of adverse reactions,lung function indicators(forced expiratory volume in 1 second[FEV1],forced exhalation in 1 second/forced vital capacity[FEV1/FVC])and blood gas analysis indicators(partial blood carbon dioxide pressure[PaCO2],partial blood oxygen pressure[PaO2])of the two groups were compared.Results The total effective rate of the analysis group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,FEV1 and FEV1/FVC in the analysis group were higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the PaO2 in the analysis group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,PaCO2 in the analysis group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of thymosin and bromhexine hydrochloride in elderly patients with pulmonary infection secondary to COPD can promote the recovery of patients more effectively,worthy of clinical application.