降钙素原指导重症感染患者抗生素应用的临床效果

Clinical effect of procalcitoninin guiding antibiotics in patients with severe infection

目的探讨降钙素原(PCT)指导重症感染患者抗生素应用的临床效果。方法选取2017年5月~2019年2月我院治疗的100例重症感染患者,根据随机数字表法分为常规治疗组和PCT指导组,每组各50例。常规治疗组实施常规抗生素治疗,PCT指导组则实施PCT指导抗生素应用治疗。比较两组治疗总有效率;感染控制、抗生素使用、总住院时间;治疗前后患者C反应蛋白监测水平及白细胞计数、PCT、多重耐药菌感染出现率。结果PCT指导组治疗总有效率高于常规治疗组,差异有统计学意义(P<0.05)。PCT指导组感染控制、抗生素使用、总住院时间短于常规治疗组,差异有统计学意义(P<0.05)。PCT指导组C反应蛋白监测水平及白细胞计数、PCT低于常规治疗组,差异有统计学意义(P<0.05)。PCT指导组多重耐药菌感染率为2%(1/50),低于常规治疗组的18%(9/50),差异有统计学意义(P<0.05)。结论PCT指导重症感染患者抗生素应用治疗效果确切,可获得理想效果,可有效缩短抗生素使用时间,还可减少多重耐药菌感染的发生。

Objective To investigate the clinical effect of procalcitonin(PCT)in guiding antibiotics in patients with severe infection.Methods A total of 100 patients with severe infections from May 2017 to February 2019 treated in our hospital were selected.According to the random number table method,patients were divided into conventional treatment group and PCT guide group,50 cases in each group.The conventional treatment was treated with conventional antibiotics treatment,and the PCT guide group was treated with PCT to guide the treatment of antibiotics.The total effective rate of the two groups was compared;the time of infection control,the average time of antibiotic use,the total length of hospital stay,the level of C-reactive protein monitoring before and after treatment,and the white blood cell count,PCT and the incidence of multi-drug resistant infection of the two groups was compared.Results The total effective rate of the PCT guide group was higher than that of the conventional treatment group,and the difference was statistically significant(P<0.05).The time to control the infection,the antibiotic use time,and the total hospital stay of the PCT guide group were shorter than those of the conventional treatment group,the differences were statistically significant(P<0.05).The level of C-reactive protein in the PCT guide group and the white blood cell count,PCT were lower than those in the conventional treatment group,and the differences were statistically significant(P<0.05).The rate of multidrug-resistant infection in the PCT guide group was 2%(1/50),which was lower than that in the conventional treatment group for 18%(9/50),and the difference was statistically significant(P<0.05).Conclusion PCT can guide the treatment of severe infections,it can achieve the desired effect,can effectively shorten the time of antibiotic use,and reduce the incidence of multi-drug resistant infection.