替吉奥联合奥沙利铂对于进展期大肠癌的化疗疗效探讨

Discussion on the Chemotherapy Efficacy of Tegafur, Gimeracil and Oteracil Capsules Combined with Oxaliplatin on Advanced Colorectal Cancer

目的探讨替吉奥联合奥沙利铂对于进展期大肠癌的化疗疗效。方法选取2016年1月至2019年1月我院收治的65例进展期大肠癌患者,根据治疗方法不同分为对照组(n=32)和观察组(n=33)。对照组采用卡培他滨联合奥沙利铂治疗,观察组采用替吉奥联合奥沙利铂治疗,对比两组的临床治疗效果及不良反应发生情况。结果观察组的治疗总有效率为96.97%,明显高于对照组的81.25%(P<0.05)。观察组的白细胞下降、血小板下降、肝功能受损、脱发发生率均明显低于对照组(P<0.05)。结论采用替吉奥联合奥沙利铂治疗进展期大肠癌患者疗效显著,不良反应较少。

Objective To explore the chemotherapy efficacy of tegafur,gimeracil and oteracil capsules combined with oxaliplatin on advanced colorectal cancer.Methods 65 cases of patients with advanced colorectal cancer admitted to our hospital from January 2016 to January 2019 were selected and divided into control group(n=32)and observation group(n=33)according to different treatment methods.The control group was treated with capecitabine and oxaliplatin,and the observation group was treated with tegafur,gimeracil and oteracil capsules combined with oxaliplatin.The clinical treatment effect and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.97%,significantly higher than 81.25%in the control group(P<0.05).The incidences of leukopenia,thrombocytopenia,liver function injury and baldness in the observation group were significantly lower than those in the control group(P<0.05).Conclusions Tegafur,gimeracil and oteracil capsules combined with oxaliplatin in the treatment of patients with advanced colorectal cancer has significant effect,and fewer adverse reactions.